Description

Bradykinin is an autocoid released from endothelial cells during ischemia and reperfusion, and it has the potential to mitigate reperfusion injury. However, its benefits are limited because it is quickly inactivated by enzymes present on the endothelial cells. One such enzyme is aminopeptidase P2. To address this, we developed a potent and selective inhibitor of aminopeptidase P2, named ST-115, which is [(S)-2-mercapto-4-methylpentanoyl]-4(S)-fluoro-Pro-Pro-3(R)-beta-Pro. When administered intravenously at the onset of reperfusion, ST-115 effectively reduces the degradation of bradykinin.

SEQUENCE: [(S)-2-mercapto-4-methylpentanoyl]-4(S)-fluoro-Pro-Pro-3(R)-beta-Pro

ONE-LETTER SEQUENCE: [(S)-2-mercapto-4-methylpentanoyl]-4(S)-fluoro-PP-3(R)-beta-P

MOLECULAR FORMULA: C₂₁H₃₂FN₃O₅
MOLECULAR WEIGHT: 457.56

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cardiovascular, Anti-Inflammatory

SKU(s): 867637A, 867637B, 867637C

KEYWORDS: bradykinin, cardioprotective, myocardial infarction, ischemic stroke, reperfusion injury

REFERENCES:

1. Lenz, Morgan R., Shih-Yen Tsai, Anne E. Roessler, Yang Wang, Periannan Sethupathi, W. Keith Jones, Gwendolyn L. Kartje, and William H. Simmons. Journal of Pharmacology and Experimental Therapeutics 380, no. 3 (2022): 220-229.