Electrospray ionization mass spectroscopy (ESI-MS) as a common technique for peptide characterization, but understanding and interpreting the spectrum can be complicated due to the multiplicity of the data.

In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...

Solid-phase peptide synthesis approaches require that the side chains of certain amino acids be protected from undesired reactivity during synthesis. The installation and removal of these protection groups results in a lower atom economy…

Mass spectroscopy-based techniques have evolved as a powerful tool in proteomics. Stable isotope-labeled peptides (SIL peptides) are chemically and physically indistinguishable from their endogenous counterparts with respect to retention time, ionization efficiency, and fragmentation pathways.

This white paper explores the click cyclization of RP-182, a promising cancer immunotherapy candidate. Our innovative approach showcases the use of copper catalysis to increase the macrocyclization efficiency of longer peptides under green reaction conditions.

While traditional stapling techniques have focused on reinforcing well-known secondary structures like α-helices and β-sheets, recent innovations have opened avenues for stabilizing non-helical and irregular conformations.

Synthetic oligonucleotides constitute an important class of therapeutics developed to treat a variety of indications. Two main synthetic approaches exist for the conjugation of a peptide to an oligonucleotide: parallel and linear.

Explore this case study on how our SPPS process optimizations have enabled multi-kilo delivery of a pharmaceutically relevant decapeptide within a challenging timescale, while improving environmental impact and production costs...

Peptide macrocyclization improves stability, bioavailability, and resistance to enzymatic degradation. Macrocyclic peptides are essential in drug discovery, providing enhanced binding affinity, specificity, and pharmacokinetics for therapeutic development.