Solid-phase peptide synthesis (SPPS) offers numerous advantages over liquid-phase peptide synthesis (LPPS) for the preparation and large-scale manufacturing of synthetic peptides. Except in the case of very short sequences (fewer than five amino acids), SPPS is generally faster, more efficient, and more economical.

Explore this case study on how our SPPS process optimizations have enabled multi-kilo delivery of a pharmaceutically relevant decapeptide within a challenging timescale, while improving environmental impact and production costs...

This white paper explores the click cyclization of RP-182, a promising cancer immunotherapy candidate. Our innovative approach showcases the use of copper catalysis to increase the macrocyclization efficiency of longer peptides under green reaction conditions.

Synthetic oligonucleotides constitute an important class of therapeutics developed to treat a variety of indications. Two main synthetic approaches exist for the conjugation of a peptide to an oligonucleotide: parallel and linear.

Peptide macrocyclization improves stability, bioavailability, and resistance to enzymatic degradation. Macrocyclic peptides are essential in drug discovery, providing enhanced binding affinity, specificity, and pharmacokinetics for therapeutic development.

Mass spectroscopy-based techniques have evolved as a powerful tool in proteomics. Stable isotope-labeled peptides (SIL peptides) are chemically and physically indistinguishable from their endogenous counterparts with respect to retention time, ionization efficiency, and fragmentation pathways.