Cosmetic Peptide Overview
The peptides found naturally in the human skin play essential roles in specific biological activities as signaling molecules of different physiological processes (i.e., homeostasis, defense, immunity). Due to their great biological activity, peptides are considered promising compounds with potential applications for certain cosmetic products.
Peptides are crucial in formulating cosmetic products, especially in renowned international brands, primarily targeting anti-aging purposes. Some of the benefits of using peptide-based cosmetic products include:
- Wound Healing: Skin collagen-regeneration stimulates cell growth and wound healing (e.g., Palmitoyl pentapeptide-3).
- Nourishing: Skin is radiantly alive with fewer dark spots (e.g., Oligopeptide-68).
- Resilience: improve skin elasticity (e.g., Peptamide-6).
- Line Reducing: Skin looks smoother, with wrinkles significantly reduced (e.g., DipeptideDiaminobutyroyl, Benzylamide Diacetate).
- Hair Growth: Fight inflammation and boost healing as cell-signaling agents (e.g., Myristoyl Tetrapeptide-12, Myristoyl Hexapeptide-16, and Myristoyl Pentapeptide-17).
WHY CHOOSE CPC SCIENTIFIC?
With over 20 years of experience, CPC Scientific is a leading peptide CRDMO with capabilities to support your large-scale cosmetic manufacturing needs. Recognizing client’s diversity, we are capable of synthesizing simple to more complex cosmetic peptide ingredients based on your needs with our robust expertise and experience in peptide manufacturing.
Manufacturing Capacity
CPC Scientific has the manufacturing capacity to support your cosmetic projects from early discovery (mg quantities) through commercialization (100 kgs).
Fast Delivery Time
Delivery time is a critical component of your project’s success. We have the capacity and flexibility to accept new projects and initiate production sooner than many leading peptide manufacturers.
Green Chemistry
Green Chemistry, including minimal-protection strategies, is an important way to minimize the use of harsh solvents like diethyl ether and trifluoroacetic acid and reduce risk to the environment.
Manufacturing Expertise
We have over 20 years of peptide manufacturing experience. We can incorporate most cosmetic-based modifications (e.g., lipid moieties including, palmitoyl, dipalmitoyl, myristic acid, geranyl, farnesyl, and geranylgeranyl).
Proven Track Record
With over 20 years of expertise in peptide production, CPC Scientific has a proven track record in custom synthesis, process development, and bulk-scale manufacturing. We have experience in product development and commercial production of cosmetic peptides.
COSMETIC PEPTIDE MANUFACTURING
CAPACITY
Partner with a developer and manufacturer who can support you throughout the entire cosmetic product lifecycle.
CPC Scientific possesses the manufacturing capabilities to assist with your cosmetic peptide projects, ranging from early discovery (mg quantities) to commercialization (100 kgs). Our pre-qualified workspace and adaptable approach enable us to expedite process development and commence production earlier than many other manufacturers.
Synthesis Equipment
- Large solid- and solution-phase peptide synthesis reactors (sizes: 20-50L, 150L, 500L, and 1000L)
- Hybrid synthesis reactor
Purification Equipment
- Preparative HPLC systems with multiple flow rates
- Chromatography columns with various diameters (8, 12, 20, and 30 inch)
- Fast protein liquid chromatography (FPLC) systems
- Multiple isolated purification suites
Isolation Equipment
- Blenders and evaporators
- Manifold lyophilizers
- Tray lyophilizers (sizes: 200 L, 500 L, and 1000 L)
RELATED POSTS & RESOURCES
We are excited to share that CPC Scientific Inc. has officially received the Good Manufacturing Practice (GMP) Certificate in accordance with the ISO 22716:2007(E) Cosmetic Guidelines.
In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...
This poster introduces two methodology case studies involving minimal side-chain protection strategies for solid-phase peptide synthesis (SPPS). SPPS approaches require protecting the side chains of specific amino acids...
Solid-phase peptide synthesis approaches require that the side chains of certain amino acids be protected from undesired reactivity during synthesis. The installation and removal of these protection groups results in a lower atom economy…
We are excited to share that CPC Scientific Inc. has officially received the Good Manufacturing Practice (GMP) Certificate in accordance with the ISO 22716:2007(E) Cosmetic Guidelines.
In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...
This poster introduces two methodology case studies involving minimal side-chain protection strategies for solid-phase peptide synthesis (SPPS). SPPS approaches require protecting the side chains of specific amino acids...
Solid-phase peptide synthesis approaches require that the side chains of certain amino acids be protected from undesired reactivity during synthesis. The installation and removal of these protection groups results in a lower atom economy…
COSMETIC PEPTIDES CITATIONS
CPC Scientific peptide products manufactured for Cosmetic Applications.
Alencar-Silva, Thuany, Stefhani Martins de Barcelos, Amandda Silva-Carvalho, Mauricio Gonçalves da Costa Sousa, Taia Maria Berto Rezende, Robert Pogue, Felipe Saldanha-Araújo et al. Cells 13, no. 10 (2024): 813.
Pep 14 (ETAKHWLKGI) was synthesized by CPC Scientific (Sunnyvale, CA, USA) and reconstituted in ultrapure water. The peptide was aliquoted and stored at −20 °C until use.
Goh, Joleen Pei Zhen. Nanyang Technological University (2023)
9 generic fluorogenic substrates (CPC Scientific) (Figure S4) were added to the final concentration of 20 μM. Fluorescence was measured at Excitation/Emission=330/390 nm on BioTek Synergy H1 microplate reader and proteolytic activity was calculated as a change in relative fluorescence units per sec using the slope of the linear range for this signal.
Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.
Zonari, A.; Brace, L. E.; Al-Katib, K.; Porto, W. F.; Foyt, D.; Guiang, M.; Cruz, E. A. O.; Marshall, B.; Gentz, M.; Guimaraes, G. R.; Franco, O. L.; Oliveira, C. R.; Boroni, M.; Carvalho, J. L., NPJ Aging 2023, 9 (1), 10.
The top hit peptides selected (Pep 14, 144, 156, 195, and 393) from the screening and the fluorescence labeled peptide (5FAM-PEG2-Pep 14) were purchased from CPC Scientific Inc. (USA), which synthesized the peptide by solid phase (Fmoc) on a Rink amide resin, with >95% purity, in the form of acetate salt.
Zonari, A., Brace, L.E., Alencar-Silva, T., Porto, W.F., Foyt, D., Guiang, M., Cruz, E.A.O., Franco, O.L., Oliveira, C.R., Boroni, M. and Carvalho, J.L. Toxicology Reports 9 (2022): 1632-1638.
Peptide 14 (ETAKHWLKGI) (Sup. Fig. 1) was purchased from CPC Scientific Inc. (USA), which synthesized the peptide by solid phase (Fmoc) on a Rink amide resin, with > 95% purity, in the form of acetate salt.
Cesaro, Angela, Marcelo DT Torres, Rosa Gaglione, Eliana Dell’Olmo, Rocco Di Girolamo, Andrea Bosso, Elio Pizzo et al. ACS Nano 16, no. 2 (2022): 1880-1895.
Expression and isolation of recombinant peptides were carried out as previously described.20 CATH-2 and (ri)-r(P)ApoBSPro peptides were obtained from CPC Scientific Inc. (Sunnyvale, CA) and CASLO ApS (Kongens Lyngby, Denmark), respectively.
Zonari, A.; Brace, L. E.; Al-Katib, K. Z.; Porto, W. F.; Foyt, D.; Guiang, M.; Cruz, E. A. O.; Marshall, B.; Salgueiro, W. G.; Inan, M. D., bioRxiv 2020, 2020.10. 30.362822.
The top hits peptides selected (peptide 14, 144, 156, 195, and 393) from the screening were purchased from CPC Scientific Inc.
Fumakia, M. MS Thesis, University of Manitoba 2016.
LL37 (host defense peptide) (Table 2) was a purchased from (custom synthesized by CPC Scientific Inc., CA, USA)
Cosmetic Peptides Flyer Request
The peptides found naturally in the human skin play essential roles in specific biological activities as signaling molecules of different physiological processes (i.e., homeostasis, defense, immunity). Due to their great biological activity, peptides are considered promising compounds with potential applications for certain cosmetic products. CPC Scientific possesses the manufacturing capabilities to assist with your cosmetic peptide projects, ranging from early discovery (mg quantities) to commercialization (100 kgs). Our pre-qualified workspace and adaptable approach enable us to expedite process development and commence production earlier than many other manufacturers.
Flyer Request Form
LIPOPEPTIDE CITATIONS
CPC Scientific peptide products manufactured with lipidation modifications.
Diao, J., Komura, R., Sano, T., Pantua, H., Storek, K.M., Inaba, H., Ogawa, H., Noland, C.L., Peng, Y., Gloor, S.L. and Yan, D. Journal of Bacteriology 203, no. 13 (2021): 10-1128.
- Departments of Infectious Diseases, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, Protein Chemistry, Early Discovery Biochemistry, Genentech, South San Francisco, California, USA
For the Lgt biochemical assay, the Pal-IAAC and Pal-IAAA peptides were synthesized by CPC Scientific.
Pantua, H., Skippington, E., Braun, M.G., Noland, C.L., Diao, J., Peng, Y., Gloor, S.L., Yan, D., Kang, J., Katakam, A.K. and Reeder, J. MBio 11, no. 5 (2020): 10-1128.
- Departments of Infectious Diseases, OMNI Bioinformatics, Chemistry, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, Molecular Biology, Genentech, South San Francisco, California, USA
MQLNKV-L(U13C6,15N)-KGL(U13C6,15N)MIALPVMAIAA-dipalmitoyl2C-SSNKNGG-K-biotin, which upon cleavage by LspA, yields the product peptide dipalmitoyl2C-SSNKNGG-K-biotin. A product standard [dipalmitoyl2C-SSNKNAAK-(NHCH2CH2NH)-biotin; CPC Scientific] was in the reaction mixture as an internal standard for normalization of product quantitation.
Buss, Colin G., and Sangeeta N. Bhatia. Proceedings of the National Academy of Sciences (2020).
Tandem Peptides. Tandem peptides were purchased from CPC Scientific. Sequences are: mTP-TAMRA-LyP1 (Myr-GWTLNSAGYLLGKINLKALA-ALAKKILGGGGK(5TAMRA)-CGNKRTRGC (C-C bridge)); [..] PEGylated formulations of these peptides were synthesized as previously described (49). The sequences are: [..] mTP-PEG-ARAL (Myr-GWTLNSAGYLLGKINLKALA-ALAKKILC-PEG5K-GGGARALPSQRSR).
Lo, J.H., Hao, L., Muzumdar, M.D., Raghavan, S., Kwon, E.J., Pulver, E.M., Hsu, F., Aguirre, A.J., Wolpin, B.M., Fuchs, C.S. and Hahn, W.C. Molecular Cancer Therapeutics 17, no. 11 (2018): 2377-2388.
pTP-TAMRA-iRGD (CH3(CH)15-[GWTLNSAGYLLGKINLKALAALAKKIL-GGK(TAMRA)GGCRGDKGPDC, Cys-Cys bridge]) used in all figures except Fig. S1 was synthesized by CPC Scientific.
Gilles, Maud-Emmanuelle, Slack, Frank J, et al. Oncotarget, 2019, Vol. 10, (No. 51), pp: 5349-5358
"Tandem peptide (pTP-iRGD: CH3(CH)15-GWTLNSAGYLLGKINLKALAALAKKIL-GGK(TAMRA)GGCRGDKGPDC, Cys-Cys bridge) was synthesized by CPC Scientific."
Kwon, Ester J., et al. Advanced Materials 29.35 (2017).
"[..] synthesized for initial screening with FAM-conjugated lysine at the C-terminal end of the membrane-interactive peptide and with or without D[KLAKLAK]2 on the C-terminus using standard Fmoc chemistry[..] All peptides were synthesized with N-terminal myristic acid and C-terminal amine. [..] larger quantities of the peptides were synthesized by CPC Scientific to 90% purity"
Noland, Cameron L., et al. Proceedings of the National Academy of Sciences 114.30 (2017): E6044-E6053.
- Departments of Structural Biology, Infectious Diseases, Biochemical and Cellular Pharmacology, Pathology, Translational Immunology, and Biomolecular Resource Group, Genentech, Inc., South San Francisco, CA 94080.
"..peptide substrates were synthesized based on the Pal lipoprotein, Pal peptideshort (Pam2Cys-SSNKNGGK-Biotin; CPC Scientific, Inc.).."
Lo, Justin H., et al. Bioconjugate Chemistry (2016).
"Myristoyl-transportan−LyP-1 tandem peptide was synthesized by CPC Scientific (sequence: myr-GGWTLNSAGYLLGKINLKALAALAKKIL-GGGG-CGNKRTRGC, Cys−Cys bridge). FAM-labeled LyP-1 bearing an azide (azidoacetyl-GGG-cyclo-(EGNKRTRGK)), FAM-labeled LyP-1 bearing a cysteine (C-K(5FAM)-C6-cyclo-(CGNKRTRGC)) and transportan bearing a C-terminal cysteine (myristic acid-GGWTLNSAGYLLGKINLKALAALAKKILC) were synthesized by CPC Scientific, Inc."
Kwon, Ester J., Matthew Skalak, Riana Lo Bu, and Sangeeta N. Bhatia. ACS Nano 10, no. 8 (2016): 7926-7933.
"[The peptides] were synthesized by CPC Scientific with N-terminal myristic acid."
Longo, Edoardo, et al. International Journal of Pharmaceutics 472.1 (2014): 156-164.
"[palmitoylated peptides] were synthesized by CPC Scientific Inc. (Sunnyvale, CA, USA), each obtained as a white lyophilised powder and stored at 4 °C protected from light. All peptides were synthesized by peptide solid-phase synthesis."