Description

Possessor of vasodilatory activity and proposed modulator of receptor-mediated pulmonary vascular contraction by influence of Ca2+ influx. This fragment has also been suggested to be an endothelium-dependent vasodilator agent in pulmonary vascular bed in rats and a vascular phase modulator in inflammation.

SEQUENCE: H-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (trifluoroacetate salt)
(Cys4 and Cys9 bridge)

ONE-LETTER SEQUENCE: SFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2(C4&C9 bridge)

MOLECULAR FORMULA: C₂₀₀H₃₀₈N₅₈O₅₉S₂

MOLECULAR WEIGHT: 4533.17

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [154765-05-6]

SYNONYMS: Adrenomedullin (13-52) (human)

RESEARCH AREA: Cardiovascular

REFERENCES:
Heaton, J. O. H. N., et al. American Journal of Physiology-Heart and Circulatory Physiology 268.6 (1995): H2211-H2215.
Sone, Masahiko, et al. Peptides 18.8 (1997): 1125-1129.
Hyman, Albert L., et al. American Journal of Physiology-Heart and Circulatory Physiology 43.4 (1998): H1218.
Gumusel, Bulent, et al. American Journal of Physiology-Heart and Circulatory Physiology 274.4 (1998): H1255-H1263.
Chu, Duc Quyen, et al. British journal of pharmacology 130.7 (2000): 1589-1596.

SKU(s): ADRM-004A, ADRM-004B

KEYWORDS: