Description

The adrenomedullin (ADM) precursor fragment is used in diagnosing several disease states, such as the dysfunction of the cardiovascular system and sepsis. The released amounts of these peptides is a reflection of the stoichiometric generation of ADM and proADM. ADM cannot be easily determined directly, because of the masking by binding proteins, instability in serum and stickiness to surfaces.

SEQUENCE: H-Glu-Leu-Arg-Met-Ser-Ser-Ser-Tyr-Pro-Thr-Gly-Leu-Ala-Asp-Val-Lys-Ala-Gly-Pro-Ala-Gln-Thr-Leu-Ile-Arg-Pro-Gln-Asp-Met-Lys-Gly-Ala-Ser-Arg-Ser-Pro-Glu-Asp-Ser-Ser-Pro-Asp-Ala-Ala-Arg-Ile-Arg-Val-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ELRMSSSYPTGLADVKAGPAQTLIRPQDMKGASRSPEDSSPDAARIRV

MOLECULAR FORMULA: C₂₁₅H₃₅₉N₆₇O₇₃S₂

MOLECULAR WEIGHT: 5114.8

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [166798-69-2]

SYNONYMS:

RESEARCH AREA: Cardiovascular

REFERENCES:
J.Struck et al., Peptides , 25, 1369 (2004)

SKU(s): ADRM-008A, ADRM-008B

KEYWORDS: