Description

C-terminal fragment found to induce dose-dependent and endothelium-independent vasodilatation on arterial mesenteric vasculator, though inactive on the venous side of tested rat perfused mesentric bed. This peptide thus shares similar properties to those of CGRP (human)

SEQUENCE: H-Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (trifluoroacetate salt)
(Cys4 and 9 bridge)

ONE-LETTER SEQUENCE: STGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGY-NH2 (Cys4 and 9 bridge)

MOLECULAR FORMULA: C₁₉₄H₃₀₄N₅₈O₅₉S₄

MOLECULAR WEIGHT: 4521.17

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [163648-32-6]

SYNONYMS: Adrenomedullin (11-50) (rat)

RESEARCH AREA: Cardiovascular

REFERENCES:
N.Berthiaume et al., Can. J. Physiol. Pharmacol., 73, 1080 (1995)
A.M.Elhawary et al., Br. J. Pharmacol., 115, 1133 (1995)

SKU(s): ADRM-010A, ADRM-010B

KEYWORDS: hormone