Description

The fibrils in the plaques formed in the brains of patients with Alzheimer?s disease contain significant amounts of truncated Abeta proteins. This fragments contain an N-terminal pyroglutamic acid. The g-carboxy group of glutamic acid forms a cyclic bond with the free N-terminal amino group to form pyroglutamate

SEQUENCE: Glp-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Glp-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

MOLECULAR FORMULA: C₁₈₇H₂₈₃N₅₁O₅₃S

MOLECULAR WEIGHT: 4125.68

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [161818-04-8]

SYNONYMS: (Pyr³)-Amyloid β-Protein (3-40)

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
Mok, SS. et al. J. Neurosci. Res. 61, 449 (2000)
Russo, C. et al. Nature. 405, 531 (2000)

SKU(s): AMYD-015A, AMYD-015B

KEYWORDS: