Description

Cyclized peptide that binds strongly to heparin and inhibits binding of 125 I-labeled APP to heparin (IC50= 10-7M). It also blocks the heparin sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.

SEQUENCE: Ac-Asn-Trp-Cys-Lys-Arg-Gly-Arg-Lys-Gln-Cys-Lys-Thr-His-Pro-His-NH2 (trifluoroacetate salt)
(Cys bridge)

ONE-LETTER SEQUENCE: Ac-NWCKRGRKQCKTHPH-NH2 (Cys and bridge)

MOLECULAR FORMULA: C₈₁H₁₂₈N₃₂O₁₉S₂

MOLECULAR WEIGHT: 1918.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [289634-54-4]

SYNONYMS: Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized), Ac-APP₇₇₀ (96-110) (cyclized)

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
D.H. Small et al., J. Neurosci., 14, 2117 (1994)

SKU(s): AMYD-028A, AMYD-028B

KEYWORDS: