Description

Pentapeptide that inhibited amyloid formation in vitro and prevented amyloid neurotoxicity in cell culture. It also has the capacity to reduce in vivo cerebral Abeta deposition and to completely block amyloid fibril formation in rat brain.

SEQUENCE: H-Leu-Pro-Phe-Phe-Asp-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: LPFFD

MOLECULAR FORMULA: C₃₃H₄₃N₅O₈

MOLECULAR WEIGHT: 637.73

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [182912-74-9]

SYNONYMS: (Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21)

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
Chacon, M. A., et al. “β-sheet breaker peptide prevents A β-induced spatial memory impairments with partial reduction of amyloid deposits.” Molecular Psychiatry 9.10 (2004): 953-961

SKU(s): AMYD-032A

KEYWORDS: