Description

Fluorogenic substrate for pro-memapsin-2 containing the beta-secretase site of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 ?M and kcat = 0.24 min-1.

SEQUENCE: H-Arg-Glu(EDANS)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DABCYL)-Arg (trifluoroacetate salt)

ONE-LETTER SEQUENCE: R-E(EDANS)-EVNLDAEF-K(DABCYL)-R

MOLECULAR FORMULA: C₉₁H₁₂₉N₂₅O₂₅S₁

MOLECULAR WEIGHT: 2005.2

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [310427-94-2]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
A.K. Ghosh et al., J. Amer. Chem. Soc., 122, 3522 (2000)
J. Ermolieff et al., Biochemistry, 39, 12450 (2000)

SKU(s): AMYD-045A, AMYD-045B

KEYWORDS: dye-labeled, FRET Substrate