Description

beta-Secretase Substrate II used for assaying beta-secretase activity and corresponds to the ‘Swedish’ Lys-Met/Asn-Leu mutation of amyloid precursor protein (APP) beta-secretase cleavage site.

SEQUENCE: H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SEVNLDAEFR

MOLECULAR FORMULA: C₅₀H₇₈N₁₄O₁₉

MOLECULAR WEIGHT: 1179.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [186142-28-9]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
F. Grüninger-Leitch, et al., Nat. Biotechnol. 18, 66 (2000)
S. Sinha, et al., Nature 402, 537 (1999)
R. Vasser, et al., Science 286, 735 (1999)
R. Yan, et al., Nature 402, 533 (1999)

SKU(s): AMYD-046A, AMYD-046B

KEYWORDS: