Description

Peptide substrate that corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer’s disease, henceforth referred to as the “Swedish “mutation. The peptide has been used for assaying cleavage at leucine-aspartate by cathespin G and chymotrypsin, whereas neither cathepsin B, D, nor L generated any products.

SEQUENCE: H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-OH (acetate salt)

ONE-LETTER SEQUENCE: SEVNLDAEF

MOLECULAR FORMULA: C₄₄H₆₆N₁₀O₁₈

MOLECULAR WEIGHT: 1023.07

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [150234-52-9]

SYNONYMS: (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675)

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
M. Citron et al., Nature, 360, 672 (1992)
M. Mullan et al., Nature Gen., 1, 345 (1992)
S.R. Sahasrabudhe et al., J. Biol. Chem., 268, 16699 (1993)

SKU(s): AMYD-047A

KEYWORDS: