Description

This peptide comprises a Cu2+-binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid beta/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer’s disease.

SEQUENCE: H-Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: FLHQERMDVCETHLHWHTVAK

MOLECULAR FORMULA: C₁₁₆H₁₇₃N₃₅O₃₁S₂

MOLECULAR WEIGHT: 2618

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [315229-44-8]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
G.Multhaup et al., Science, 271, 1406 (1996)

SKU(s): AMYD-048A, AMYD-048B

KEYWORDS: