Description

This peptide is the English (H6R) mutation of beta-amyloid, which accelerates fibrillation without increasing protofibril formation. The English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His6 by Arg influences the structure of the Cu2+ complex formed by Abeta peptides.

SEQUENCE: H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

MOLECULAR FORMULA: C₁₉₄H₃₀₀N₅₄O₅₈S₁

MOLECULAR WEIGHT: 4348.91

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [1802084-26-9]

SYNONYMS: [Arg6]-beta-Amyloid (1-40), England Mutation

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
Y.Hori et al., J. Biol. Chem., 282, 4916 (2007)
K.Ono et al., J. Biol. Chem., 285, 23186 (2010)
B.Alies et al., Inorg. Chem., 50, 11192 (2011)

SKU(s): AMYD-050A, AMYD-050B

KEYWORDS: