Description

This peptide is the biologically active domain of the amyloid beta-protein for neurotrophic and neurotoxic effects, which is homologous to a region in peptides of the tachykinin family.

SEQUENCE: H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GSNKGAIIGLM

MOLECULAR FORMULA: C₄₅H₈₁N₁₃O₁₄S₁

MOLECULAR WEIGHT: 1060.28

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [131602-53-4]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
B.A.Yankner et al., Science, 250, 279 (1990)
A.Klegeris et al., Biochem. Biophys. Res. Commun., 199, 984 (1994)
C.J.Pike et al., Neuroscience, 63, 517 (1994)
C.J.Pike et al., J. Neurochem., 64, 253 (1995)
J.H.Ippel et al., Proc. Natl. Acad. Sci. USA, 99, 8648 (2002)
M.E.Clementi et al., FEBS Lett., 579, 2913 (2005)
F.Misiti et al., Neurochem. Int., 46, 575 (2005)
G.Wei and J.-E.Shea, Biophys. J., 91, 1638 (2006)
D.Buntup et al., Neurochem. Res., 33, 248 (2008)
I.D.Limon et al., Neurosci. Res., 63, 129 (2009)
L.Millucci et al., Curr. Protein Pept. Sci., 11, 54 (2010)
H.-H.G.Tsai et al., Proteins, 78, 1909 (2010)

SKU(s): AMYD-051A, AMYD-051B

KEYWORDS: