Description

This peptide was isolated from the insoluble core of Alzheimer’s disease (AD) amyloid plaque. It is the fragment (61-95) of NACP or alpha-synuclein and forms amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.

SEQUENCE: H-Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV

MOLECULAR FORMULA: C₁₄₁H₂₃₅N₃₉O₄₉

MOLECULAR WEIGHT: 3260.65

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [154040-19-4]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
H.Han et al., Chemistry and Biology, 2, 163 (1995)
A.Iwai et al., Biochemistry, 34, 10139 (1995

SKU(s): AMYD-052A, AMYD-052B

KEYWORDS: