Description

Fluorogenic substrate for pro-memapsin-2 containing the b-secretase site of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 4.5 ?M and kcat = 0.25 min-1.

SEQUENCE: MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DNP)-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Mca-SEVNLDAEF-Lys(Dnp)

MOLECULAR FORMULA: C₆₈H₈₈N₁₄O₂₇

MOLECULAR WEIGHT: 1533.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [1802078-31-4]

SYNONYMS: Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675)-Lys(Dnp)

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
J.Ermolieff et al., Biochemistry, 39, 16263 (2000)
J.Ermolieff et al., Biochemistry, 39, 12450 (2000)

SKU(s): AMYD-107A, AMYD-107B

KEYWORDS: dye-labeled, FRET Substrate