Description

Fluorescent peptide substrate that contains the wild-type amyloid precursor protein (APP) beta-secretase cleavage site. It is used for assaying beta-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). Studies reveal that TOP is a potential beta-secretase candidate and is involved in the processing of APP in vivo.

SEQUENCE: MCA-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(DNP)-Arg-Arg-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Mca-SEVKMDAEFR-K(DNP)-RR-NH2

MOLECULAR FORMULA: C₈₇H₁₂₉N₂₇O₂₈S₁

MOLECULAR WEIGHT: 2033.2

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
H. Koike et al., J. Biochem., 126, 235 (1999)

SKU(s): AMYD-110A, AMYD-110B

KEYWORDS: dye-labeled, FRET Substrate