Description

beta-Secretase Inhibitor II is a potent, cell permeable, and reversible inhibitor of β-secretase corresponding to the β-secretase cleavage site of Swedish mutant Amyloid Precursor Protein (APP). This peptide inhibits the formation of both Aβtotal (IC₅₀ = 700 nM) and Aβ1-42 (IC₅₀ = 2.5 µM) in CHO cells transfected with wild-type APP751.

SEQUENCE: Z-Val-Leu-Leu-CHO

ONE-LETTER SEQUENCE: ZVLL-CHO

MOLECULAR FORMULA: C₂₅H₃₉N₃O₅

MOLECULAR WEIGHT: 461.59

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [263563-09-3]

SYNONYMS: β-Secretase Inhibitor II

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
G. Abbenante, et al., Biochem. Biophys. Res. Commun. 268, 133 (2000)

SKU(s): AMYD-113A

KEYWORDS: aldehyde (CHO)