Description

Amylin (8-37) is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. The peptide has a systemic increase in insulin sensitivity and has shown to reduce basal insulin levels in both normal and hGH-induced insulin-resistant rats.

SEQUENCE: H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ATQRLANFLVHSSNNFGAILSSTNVGSNTY

MOLECULAR FORMULA: C₁₃₈H₂₁₅N₄₁O₄₆

MOLECULAR WEIGHT: 3184.45

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [135702-23-7]

SYNONYMS: Amylin (8-37) (human)

RESEARCH AREA: Diabetes

REFERENCES:
Deems, R.O. et al. Biochem. Biophys. Res. Commun., 181, 116 (1991)
Kaygisiz, Z. et al. Acta Physiol. Hung. 90, 133 (2003)
B.Konarkowska et al., FEBS J., 272, 4949 (2005)

SKU(s): AMYN-003A, AMYN-003B

KEYWORDS: hormone