Description

13-residue peptide amide isolated and characterized from the cytoplasmic granules of bovine neutrophils, having potent antibacterial activity. It is also highly cytotoxic to T-line cells. Furthermore, the primary structure of indolicidin is characterized by 5 tryptophan residues, which is the highest mole percentage of any known protein sequence and is unique among known endogenous antibacterial peptides.

SEQUENCE: H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ILPWKWPWWPWRR-NH2

MOLECULAR FORMULA: C₁₀₀H₁₃₂N₂₆O₁₃

MOLECULAR WEIGHT: 1906.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [140896-21-5]

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
C. Subbalakshmi et al., FEBS Letters, 395, 48 (1996)

SKU(s): ATBP-004A, ATBP-004B

KEYWORDS: