Description

31 amino acid peptide that is highly potent against Gram-negative bacteria but has a reduced activity against Gram-positive bacteria. A disruptive effect on bacterial membranes has been proposed as mechanism of antimicrobial activity.

SEQUENCE: H-Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SWLSKTAKKLENSAKKRISEGIAIAIQGGPR

MOLECULAR FORMULA: C₁₄₇H₂₅₃N₄₅O₄₃

MOLECULAR WEIGHT: 3338.9

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [125667-96-1]

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
J.Y. Lee et al., PNAS, 86, 9159 (1989)

SKU(s): ATMP-004A, ATMP-004B

KEYWORDS: