Description

Peptide that is isolated from skin extracts of the South American arboreal frog, Phyllomedusa Sauvagei. It is a strongly basic, water-soluble, thermalstable nonhemolytic compound, nonhemolytic peptide that exhibits highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. A potential amphiphatic alpha-helix structure can probably function by membrane permeabilization.

SEQUENCE: H-Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ

MOLECULAR FORMULA: C₁₅₂H₂₅₇N₄₃O₄₄S₂

MOLECULAR WEIGHT: 3455.11

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [136033-70-0]

SYNONYMS:

RESEARCH AREA: Antimicrobial

REFERENCES:
A. Mor et al., Biochemistry, 30, 8824 (1991)

SKU(s): ATMP-005A, ATMP-005B

KEYWORDS: