Description

A potent and reversible cell permeable proteasome inhibitor (Kj 4 nM) of 20S proteasome and calpain. Also shown to initiate neurite outgrouth in PC12 cells with an optimal concentration set at 20 nM.

SEQUENCE: Z-Leu-Leu-Leu-CHO

ONE-LETTER SEQUENCE: Z-LLL-CHO

MOLECULAR FORMULA: C₂₆H₄₁N₃O₅

MOLECULAR WEIGHT: 475.63

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [133407-82-6]

SYNONYMS: Calpain Inhibitor IV, MG 132, MG132

RESEARCH AREA: Cancer

REFERENCES:
D.H. Lee et al., J. Biol. Chem., 271, 27280 (1996)
K. L. Rock et al, Cell, 78, 761 (1994)

SKU(s): CALI-001A

KEYWORDS: aldehyde (CHO)