Description

The peptide acts as a calmodulin agonist, interacts with the calmodulin EF-hand motif, the Ca2+ binding site. CALP-3 activates the phosphodiesterase in the absence of Ca2+ and inhibits cytotoxicity and apoptosis in a Ca2+ mediated manner.

SEQUENCE: H-Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: VKFGVGFK

MOLECULAR FORMULA: C₄₄H₆₈N₁₀O₉

MOLECULAR WEIGHT: 881.09

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [261969-05-5]

SYNONYMS:

RESEARCH AREA: Apoptosis

REFERENCES:
M.Villain et al., J. Biol. Chem., 275, 2676 (2000)
M.K.Manion et al., FASEB J., 14, 1297 (2000)
R.Ten Broeke et al., FASEB J., 15, 1831 (2001)
R.Ten Broeke et al., Eur. J. Pharmacol., 476, 151 (2003)

SKU(s): CALP-002A, CALP-002B

KEYWORDS: