Description

This peptide is tumor suppressor protein, p53 (368-393). There is a biotinylated lyine followed by a GG linker at the N-terminal and an acetylated lysine at lysine 373. Activation of the p53 protein results in the transcription of antiproliferative proteins and induction of apoptosis. The p53 tumor suppressor is a principal mediator of growth arrest, senescence, and apoptosis in response to a broad array of cellular damage.

SEQUENCE: Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys-Lys(Ac)-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Biotin-KGGHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 3481

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Kanovsky, M. et al. Proc Natl Acad Sci 98, 12438 (2001)

SKU(s): CANC-002A, CANC-002B

KEYWORDS: