Description

This peptide is tumor suppressor protein p53 (368-393). There is a biotinylated lysine follwed by a GG linker at the N-terminal and is acetylated at lysine 382. p53 is an ideal tumor suppressor gene because of its ability to control cell proliferation, and senescence. In response to cell stress, cell damage, or ectopic oncogene, p53 also mediates apoptosis.

SEQUENCE: Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys(Ac)-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Biotin-KGGHLKSKKGQSTSRHK-K(Ac)-LMFKTEGPDSD-NH2

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 3481

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Ghosh, A. et al. Mol. Cell Biol. 24, 7987 (2004)

SKU(s): CANC-005A, CANC-005B

KEYWORDS: