Description

This is an amidated peptide derived from amino acid residues 372-389 of human p53 tumor suppressor protein with acetylation at Lys382. It is biotinylated at its N-terminus through a 6-carbon LC linker. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo

SEQUENCE: Biotin-LC-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys(Ac)-Leu-Met-Phe-Lys-Thr-Glu-Gly-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Biotin-LC-KKGQSTSRHK-K(Ac)-LMFKTEG-NH2

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 2472

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Kubbutat, M. et al. Lett. Nature 387, 299 (1997)
Li, M. et al. J. Biol. Chem. 277, 50607 (2002)

SKU(s): CANC-007A, CANC-007B

KEYWORDS: