Description

p53K370Me2 is derived from amino acid residues 361-380 of human p53 tumor suppressor protein, with dimethylation at Lys370. This peptide promotes p53 interactions with both p21gene promoters and p53 binding protein 1 (53BP1), activating transcription of p53 target genes

SEQUENCE: H-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys(Me2)-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GSRAHSSHL-K(Me2)-SKKGQSTSRH

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 2204.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Egorova, K. Biochem 75, 535 (2010)

SKU(s): CANC-011A, CANC-011B

KEYWORDS: