Description

This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.

SEQUENCE: Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys(Me2)-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Biotin-KGGHLKS-K(Me2)-KGQSTSRHKKLMFKTEGPDSD-NH2

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 3467

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Huang, J. et al. Nature 440, 629 (2006)

SKU(s): CANC-012A, CANC-012B

KEYWORDS: