Description

p53K382Me2 is derived from amino acid residues 377-387 of human p53 tumor suppressor protein, with dimethylation at Lys382. DNA damage induces increased levels of this peptide, which is recognized by p53-binding protein 1 (53BP1). 53BP1 interacts with p53 and modulates its transactivation.

SEQUENCE: H-Thr-Ser-Arg-His-Lys-Lys(Me2)-Leu-Met-Phe-Lys-Thr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: TSRHK-K(Me2)-LMFKT

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 1404.7

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Kachirskaia, I. et al. J Biol Chem 283, 34660 (2008)

SKU(s): CANC-013A, CANC-013B

KEYWORDS: