Description

This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development.

SEQUENCE: H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ETFSDLWKLL

MOLECULAR FORMULA: C₆₀H₉₁N₁₃O₁₆

MOLECULAR WEIGHT: 1250.45

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [488118-64-5]

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006)
Kanovsky, M. et al. PNAS 98, 12438 (2001)

SKU(s): CANC-016A

KEYWORDS: