Description

This is amino acids 17 to 26 fragment of p53, fluorescent labeled through an LC spacer. This peptide is the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that come into contact with the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development, FITC (Abs/Em=493 nm/517 nm)..

SEQUENCE: FITC-LC-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-NH2 (ammonium salt)

ONE-LETTER SEQUENCE: FITC-LC-ETFSDLWKLL-NH2

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 1753.1

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Yu, G. et al. PNAS 103, 1227 (2006)
Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006)
Kanovsky, M. et al. PNAS 98, 12438 (2001)

SKU(s): CANC-017A

KEYWORDS: