Description

WL12 peptide selectively binds to programmed death ligand 1 (PD-L1), an immune checkpoint protein that is overexpressed in many cancer cell lines. Tumor PD-L1 expression contributes to immune system depression and is indicative of a tumor’s response to PD-L1 and PD-1.

SEQUENCE: cyclo(AcTyr-MeAla-Asn-Pro-His-Leu-Hyp-Trp-Ser-Trp(Me)-MeNle-MeNle-Orn-Cys)-Gly-NH2 (trifluoroacetate salt)
(Thioether bridge: Cys14-Ac-Tyr)

ONE-LETTER SEQUENCE: cyclo(AcY-MeANPHL-Hyp-WSW(Me)-MeNle-MeNle-OC)-G-NH2 (trifluoroacetate salt)
(Thioether bridge: C14-Ac-Y)

MOLECULAR FORMULA: C₉₁H₁₂₈N₂₂O₂₀S

MOLECULAR WEIGHT: 1882.19

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

CITATIONS:
Lesniak, Wojciech G. et al. Molecular Imaging 18 (2019). »
Chatterjee, Samit et al. Biochemical and Biophysical Research Communications 483, no. 1 (2017): 258-263. »
De Silva, Ravindra A. et al. Molecular Pharmaceutics 15, no. 9 (2018): 3946-3952. »
Kumar, Dhiraj et al. The Journal of Clinical Investigation 129, no. 2 (2019): 616-630. »

REFERENCES:
Chatterjee, Samit, et al. “Rapid PD-L1 detection in tumors with PET using a highly specific peptide.” Biochemical and Biophysical Research Communications 483.1 (2017): 258-263.

SKU(s): CANC-022A, CANC-022B

KEYWORDS: thioether, peptide macrocycle