Description

Peptide that contains modified sequence of the gp 100 epitope gp(209-217), in which a methionine replaced the natural threonine at position 2. This peptide also binds to the HLA-A2 molecule with greater affinity than the unmodified peptide and has exhibited a good ability to stimulate melonomareactive cytotoxic T lymphocytes (CTLs) in vitro when used for sensitization of peripheral blood mononuclear cells. This synthetic peptide holds promise for the development of novel cancer immunotherapies.

SEQUENCE: H-Ile-Met-Gln-Val-Pro-Phe-Ser-Val-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: IMQVPFSV

MOLECULAR FORMULA: C₄₃H₆₉N₉O₁₁S₁

MOLECULAR WEIGHT: 920.13

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [255710-51-1]

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
S.A. Rosenberg et al., Nature Med., 4, 321 (1998)

SKU(s): CANS-004A

KEYWORDS: