Description

Metal chelating peptide Pep-1L-NOTA targets tumor-restricted receptor, IL13RA2, found to be present in some aggressive malignancies, specifically gliomas and malignant melanoma. Recent work has demonstrated that the copper-bound peptide selectively binds hIL13RA2-expressing tumors and validates its use in peptide-based PET imaging for cancer diagnostics.

SEQUENCE: H-Ala-Cys-Gly-Glu-Met-Gly-Trp-Val-Arg-Cys-Gly-Gly-Gly-Ser-C6-Lys-Lys(NOTA)-NH2 (trifluoroacetate salt)
(Reduced Cys-H)

ONE-LETTER SEQUENCE: ACGEMGWVRCGGGS-C6-K-K(NOTA)-NH2

MOLECULAR FORMULA: C₈₄H₁₃₉N₂₇O₂₅S₃

MOLECULAR WEIGHT: 2023.36

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Sai, Kiran Kumar Solingapuram, et al. “Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker.” Oncotarget 5 (2017).

SKU(s): CANS-012A

KEYWORDS: