Description

Ac-WVAD-AMC is a fluorogenic substrate for caspase-4 and caspase-1 (kcat/Km = 2.41 x 10⁵ M^-1s^-1). Ac-WVAD-AMC exhibits approximately 2 fold greater affinity towards caspase-1 than for caspase-4.

SEQUENCE: Ac-Trp-Val-Ala-Asp-AMC (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Ac-WVAD-AMC

MOLECULAR FORMULA: C₃₅H₄₀N₆O₉

MOLECULAR WEIGHT: 688.29

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [189275-74-9]

SYNONYMS: Caspase-1/Caspase-4 Substrate II, Fluorogenic, Caspase 1 (ICE) Substrate

RESEARCH AREA: Apoptosis

REFERENCES:
D. Lee, et al., Bioorg. Med. Chem. Lett. 9, 1667 (1999)
T.A. Rano, et al., Chem. Biol. 4, 149 (1997)

SKU(s): CASP-006A

KEYWORDS: dye-labeled