Description

Tetrapeptide aldehyde, a potent, specific, reversible inhibitor of caspase-1 (ICE) that displays a Ki of 0.2 ±0.1 nM for recombinant human caspase-1.

SEQUENCE: Ac-Tyr-Val-Ala-Asp-CHO

ONE-LETTER SEQUENCE: Ac-YVAD-CHO

MOLECULAR FORMULA: C₂₃H₃₂N₄O₈

MOLECULAR WEIGHT: 492.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [143313-51-3]

SYNONYMS:

RESEARCH AREA: Apoptosis

REFERENCES:
N.A. Thornberry et al., Nature 356, 768 (1992)
S.M. Molineaux et al., Proc. Natl. Acad. Sci. USA, 90, 1809 (1993)
N.P.C. Walker et al., Cell, 78, 343 (1994)

SKU(s): CASP-011A, CASP-011B

KEYWORDS: aldehyde (CHO)