Description

Fluorogenic caspase-1 (ICE) substrate that allows a continuous assay of caspase-1 useful in the screening of inhibitory compounds (Km = 11.4 µM, kcat = 0.79 s^-1)

SEQUENCE: DABCYL-Tyr-Val-Ala-Asp-Ala-Pro-Val-EDANS

ONE-LETTER SEQUENCE: DABCYL-YVADAPV-EDANS

MOLECULAR FORMULA: C₆₁H₇₆N₁₂O₁₄S₁

MOLECULAR WEIGHT: 1233.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [161877-70-9]

SYNONYMS:

RESEARCH AREA: Apoptosis

REFERENCES:
M. W. Pennington and N.A. Thornberry, Peptide Res., 7, 72 (1994)
M. Los et al., Nature, 375, 81 (1995)

SKU(s): CASP-023A, CASP-023B

KEYWORDS: dye-labeled, FRET Substrate