Description

ICE-like protease inhibitor that blocks all features of apoptosis: morphological changes, cleavage of caspase-3 (CPP32/Yama/Apopain) and poly(ADP-ribose) polymerase, lamin B degradation and DNA fragmentation.

SEQUENCE: Z-Val-Ala-DL-Asp(OMe)-FMK

ONE-LETTER SEQUENCE: Z-VA-DL-Asp(OMe)-FMK

MOLECULAR FORMULA: C₂₂H₃₀F₁N₃O₇

MOLECULAR WEIGHT: 467.50

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [634911-81-2]

SYNONYMS: Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone

RESEARCH AREA: Apoptosis

REFERENCES:
T. Shimizu et al., Leukemia, 11, 1238 (1997)
H. Hara et al., Proc. Natl. Acad. Sci. USA, 94, 2007 (1997)

SKU(s): CASP-035A, CASP-035B

KEYWORDS: fluoromethyl ketone