Description

Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).

SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Decy-RVKR-CMK

MOLECULAR FORMULA: C₃₄H₆₆Cl₁N₁₁O₅

MOLECULAR WEIGHT: 744.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [150113-99-8]

SYNONYMS: Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)

RESEARCH AREA: Apoptosis

REFERENCES:
W.Garten et al., Virology, 172, 25 (1989)
A.Stieneke-Gröber et al., EMBO J., 11, 2407 (1992)
S.Hallenberger et al., Nature, 360, 358 (1992)
W.Garten et al., Biochimie, 76, 217 (1994)
J.-B.Denault et al., FEBS Lett., 362, 276 (1995)
J.-B.Denault et al., J. Cardiovasc. Pharmacol. , 26 (Suppl.3), S47 (1995)
S.Hallenberger et al., J. Virol., 71, 1036 (1997)
S.Deb et al., J. Neurosci. Res., 55, 44 (1999)

SKU(s): CASP-089A, CASP-089B, CASP-089C, CASP-089D

KEYWORDS: