Description

A new CRF antagonist (cyclo(30/33) that, when injected into the CSF at low doses (1-10ug), results in antagonistic action against CRF and stress-related alterations of gastrointestinal motor function, without an intrinsic effect in these in vivo systems.

SEQUENCE: H-DPhe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: fHLLREVLE-Nle-ARAEQLAQ-cyclo(EAHK)NRKL-Nle-EII-NH2

MOLECULAR FORMULA: C₁₆₁H₂₆₉N₄₉O₄₂

MOLECULAR WEIGHT: 3563.24

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [170809-51-5]

SYNONYMS: (D-Phe¹²,Nle²¹·³⁸,cyclo(Glu³⁰-Lys³³))-CRF (12-41) (human, rat)

RESEARCH AREA: Neuropeptides

REFERENCES:
V. Martinez et al., J. Pharmacol. Exp. Ther., 280(2), 754 (1997)

SKU(s): CRFS-003A, CRFS-003B

KEYWORDS: hormone, lactam, peptide macrocycle