Description

Endogenous antibiotic peptide that exhibits a range of prominent anti-microbial activities against bacteria, fungi, and certain enveloped viruses.

SEQUENCE: H-Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH (trifluoroacetate salt)

(Cys2 and 30 bridge, Cys4 and 19 bridge, Cys 9 and 29 bridge)

ONE-LETTER SEQUENCE: ACYCRIPACIAGERRYGTCIYQGRLWAFCC (C2&C30 bridge, C4&C19 bridge, C 9&C29 bridge)

MOLECULAR FORMULA: C₁₅₀H₂₂₂N₄₄O₃₈S₆

MOLECULAR WEIGHT: 3442.08

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [148093-65-6]

SYNONYMS: α-Defensin-1 (Human), alpha-Defensin-1 (Human), Defensin HNP-1 human, Human Neutrophil Peptide-1, HNP-1

RESEARCH AREA: Antimicrobial

REFERENCES:
T. Ganz et al., J. Clin. Invest., 76, 1427 (1985)
M.E. Selsted et al., J. Clin. Invest., 76, 1436 (1985)
T. Ganz et al., Eur. J. Haematol, 44, 1 (1990)

SKU(s): DEFS-002A, DEFS-002B

KEYWORDS: