Description

HIV binds to the host CD4+ cell receptor via the viral protein gp120; gp41. Enfuvirtide binds to gp41 preventing the conformational changes in gp41 which is necessary for fusion of the virus with the cell.

SEQUENCE: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2

ONE-LETTER SEQUENCE: Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2

MOLECULAR FORMULA: C₂₀₄H₃₀₁N₅₁O₆₄

MOLECULAR WEIGHT: 4491.94

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [159519-65-0]

SYNONYMS: T20, Pentafuside

RESEARCH AREA: Antimicrobial

REFERENCES:
H.B.Fung and Y.Guo, Clin. Ther., 26, 352 (2004)
R.Manfredi and S.Sabbatani, Curr. Med. Chem., 13, 2369 (2006)
J.Ruof et al., Clin. Drug Investig., 27, 469 (2007)
A.Streinu-Cercel et al., HIV Clin. Trials, 9, 375 (2008)

SKU(s): ENFU-001A, ENFU-001B

KEYWORDS: