Description

Human galanin, originally been isolated from colon and pituitary, that activates the rat galanin receptor and inhibits acetylcholine release, glutamate release and carbachol-stimulated phosphatidylinositol hydrolysis in the hippocampus. Recent studies indicated that galanin is also linked to behavioral and cognitive deficits in Alzheimer’s disease.

SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS

MOLECULAR FORMULA: C₁₃₉H₂₁₀N₄₂O₄₃

MOLECULAR WEIGHT: 3157.45

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [119418-04-1]

SYNONYMS:

RESEARCH AREA: Alzheimer’s Disease

REFERENCES:
W.E. Schmidt et al., PNAS, 88, 11435 (1991)

SKU(s): GALA-001A, GALA-001B

KEYWORDS: