Description

Fragment that contains the third disulfide loop of rat TGF alpha and is an antagonist of EGF-induced mitogenesis. Studies now point out that TGF alpha (34-43) inhibits the growth of gastric cancers induced by N-methyl-N’-nitro-N-nitroso-guanidine.

SEQUENCE: H-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-OH (trifluoroacetate salt)
(Cys1 and 10 bridge)

ONE-LETTER SEQUENCE: CHSGYVGVRC (Cys1 and 10 bridge)

MOLECULAR FORMULA: C₄₄H₆₇N₁₅O₁₃S₂

MOLECULAR WEIGHT: 1078.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [97474-88-9]

SYNONYMS: TGF α(34-43) (rat)

RESEARCH AREA: Cancer

REFERENCES:
Nestor et al., BBRC, 129, 226 (1985)

SKU(s): GRFF-006A, GRFF-006B

KEYWORDS: hormone, peptide macrocycle