Description

Intestinal guanylate cyclase activator that is isolated from rat intestine and activates intestinal guanylate cyclase in a human colon carcinoma-derived cell line (T84). It resembles the heat-stable endotoxins produced by E. coli.

SEQUENCE: H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (trifluoroacetate salt)

(Cys4 and 12 bridge, Cys7 and 15 bridge)

ONE-LETTER SEQUENCE: PGTCEICAYAACTGC (C4&C12 bridge, C7&C15 bridge)

MOLECULAR FORMULA: C₅₈H₈₇N₁₅O₂₁S₄

MOLECULAR WEIGHT: 1458.68

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [183200-12-6]

SYNONYMS:

RESEARCH AREA: Gastrointestinal

REFERENCES:
R.C. Wiegand et al., FEBS Letters, 311, 150 (1992)
F.J.de Sauvage et al., Proc. Natl. Acad. Sci. USA, 89, 9089 (1992)

SKU(s): GUAN-001A, GUAN-001B

KEYWORDS: