Description

This peptide is a neurotoxin that blocks N-type calcium channels. N-type Ca2+ Channel Blocker

SEQUENCE: H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (trifluoroacetate salt)
(Disulfide bridges: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26)

ONE-LETTER SEQUENCE: CKS(Hyp)GSSCS(Hyp)TSYNCCRSCN(Hyp)YTKRCY-NH2

MOLECULAR FORMULA: C₁₂₀H₁₈₂N₃₈O₄₃S₆

MOLECULAR WEIGHT: 3037.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [106375-28-4]

SYNONYMS: ω-Conotoxin GVIA

RESEARCH AREA: Toxin

REFERENCES:
Rivier, J. et al. J. Biol. Chem. 262, 1194 (1987)
Lampe, RA. et al. Biochem. 32, 3255 (1993)
Wright, C. and JA. Angus, J. Cardiovasc. Pharmacol. 30, 392 (1997)
Serone, A. and JA. Angus, Br. J. Pharmacol. 127, 927 (1999).
B.M. Olivera, J.M. Mclntosh, L.J. Cruz, F.A. Luque, and W.R. Gray, Biochemistry, 23, 5087 (1984). (Original)
Y. Nishiuchi, K. Kumagaye, Y. Noda, T.X. Watanabe, and S. Sakakibara, Biopolymers, 25, S61 (1986). (Chem. Synthesis and S-S Bond)

SKU(s): GVIA-001A, GVIA-001B

KEYWORDS: