Description

Hepcidin-25 (hepatic bactericidal protein), also known as LEAP-1 (liver-expressed antimicrobial peptide) is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides (AMPs) that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Hepicidin is involved in iron-regulation in humans and acts by binding to the iron exporter ferroportin, causing its internalization and degradation, thereby blocking cellular iron efflux.

SEQUENCE: H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (trifluoroacetate salt)
(Disulfide bridges: Cys⁷ and Cys²³/Cys¹⁰ and Cys¹³/Cys¹¹ and Cys¹⁹/Cys¹⁴ and Cys²²)

ONE-LETTER SEQUENCE: DTHFPICIFCCGCCHRSKCGMCCKT₂

MOLECULAR FORMULA: C₁₁₃H₁₇₀N₃₄O₃₁S₉

MOLECULAR WEIGHT: 2789.40

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [1356390-47-0]

SYNONYMS: PLTR (human), LEAP-1 (human), Liver-Expressed Antimicrobial Peptide (human), Hepc25 (human), Putative Liver Tumor Regressor (human)

RESEARCH AREA: Antimicrobial

REFERENCES:
R.E.Fleming and W.S.Sly, Proc. Natl. Acad. Sci. USA, 98, 8160 (2001)
A.Krause et al., FEBS Lett., 480, 147 (2000)

SKU(s): HEPC-001A, HEPC-001B, HEPC-001C

KEYWORDS: hormone